Last updated June 2016

Primary Research

H Uhlirova, K Kılıç, P Tian, S Sakadˇzic, L Gagnon, M Thunemann, M Desjardins, PA. Saisan, K Nizar, MA Yasseen, DJ Hagler Jr, M Vandenberghe, S Djurovic, OA. Andreassen, GA Silva, E Masliah, D Kleinfeld, S Vinogradov, RB. Buxton, GT. Einevoll, DA Boas, AM Dale, and A Devor (2016) The roadmap for estimation of cell-type- specific neuronal activity from non- invasive measurements. Philosophical Transactions B. 371:20150356. PDF

GA Silva (2016) Geometric constraints on the dynamics of networks. arXiv 1510.08729. PDF

S Ha, M Khraiche, A Akinin, Y Jin, WR Freeman, GA Silva, and G Cauwenberghs (2016) Towards high-resolution retinal prostheses with direct optical addressing and inductive telemetry. Journal of Neural Engineering 13:056008. PDF

H Uhlirova, K Kilic, P Tian, PA Saisan, Q Cheng, KL Weldy2 S Sakadzic, F Razoux, M Vandenberghe, K Nizar, VB Sridhar, TC Steed, M Abashin, Y Fainman, E Masliah, S Djurovic, OA Andreassen, GT Einevoll, GA Silva, DA Boas, RB Buxton, AM Dale1, S Devor (2016) Cell type specificity of neurovascular coupling in cerebral cortex. eLife 2016;10.7554/eLife.14315. PDF

S-Y Eun, K Nguyen-Ta, GA Silva, and S-J Kim (2016) Assembly and calcium binding properties of quantum dot-calmodulin calcium sensor. Journal Nanoscience and Nanotechnology. 16:2065-2068.

CL MacDonald, N Bhattacharya, BP Sprouse, and GA Silva (2015) Efficient computation of the Grunwald-Letnikov fractional diffusion derivative using adaptive time step memory. Journal of Computational Physics 297:231-236. [arXiv 1004.5128 and 1505.03967] PDF

J Blumling III and GA Silva (2015) Sulforhodamine B-loaded polyethyleneimine/silica hybrid nanoparticles. Journal of Nanoneuroscience. 6:73-77.

M Buibas and GA Silva (2015) Algebraic identification of the effective connectivity of constrained geometric network models of neural signaling. arXiv 1505.03964. PDF

B Maranhao, P Biswas, JL Duncan KE Branham, GA Silva MA Naeem, SN Khan, S Riazuddin, JF Hejtmancik, JR Heckenlively, SA Riazuddin, PL Lee, and R Ayyagari (2014) exomeSuite: Whole exome sequence variant filtering tool for rapid identification of putative disease causing SNVs/indels. Genomics 103:169-176. PDF

CL MacDonald and GA Silva (2013) A positive feedback cell signaling nucleation model of astrocyte dynamics. Frontiers in Neuroengineering 6:4. doi: 10.3389/fneng.2013.00004. PDF

K Nizar, P Tian, Q Cheng, PA Saisan, H Uhlirova, L reznichenko, K Weldy, TY Steed, VB Sridhar, CL MacDonald, J Cui, S Sakadzic, DA Boas, TI Beka, GT Einevoll, J Chen, E Masliah, AM Dale, GA Silva, and A Devor (2013) In vivo stimulus-induced vasodilation precedes astrocytic calcium increase. Journal of Neuroscience 33:8411-8422. PDF

S-J Kim, J Blumling, MC Davidson, H Saad, S-Y Eun, and GA Silva (2012) Calcium and EDTA induced folding and unfolding of calmodulin on functionalized quantum dot surfaces. Journal of Nanoneuroscience 2:75-81. PDF

C Evans, M Fitzgerald, T Clemons, M House, B Padman, J Shaw, M Saunders, A Harvey, B Zdyrko, I Luzinov, GA Silva, S Dunlop, KS Iyer (2011) Multimodal analysis of PEI-mediated endocytosis of nanoparticles in neural cells. ACS Nano 5:8640-8648. PDF

M Buibas and GA Silva (2011) A framework for simulating and estimating the state and functional topology of complex dynamic geometric networks. Neural Computation 23:183-214. [arXiv 0908.3934].

M Buibas, D Yu, K Nizar, and GA Silva (2010) Mapping the Spatiotemporal Dynamics of Calcium Signaling in Cellular Neural Networks Using Optical Flow. Annals of Biomedical Engineering 38:2520-2531. [arXiv 0912.0265].

SK Chow, D Yu, CL MacDonald, M Buibas, and GA Silva (2010) Amyloid-β-peptide directly induces spontaneous calcium oscillations, intercellular calcium waves, and gliosis in rat cortical astrocytes. ASN Neuro 2(1):art:e00026.doi:10.1042/AN20090035. PDF

D Yu, M Buibas, Z Singer, I Lee, and GA Silva (2009) Characterization of calcium mediated intracellular and intercellular signaling in the rMC-1 glial cell line. Cellular and Molecular Bioengineering 2:144-155 .PDF

S Pathak, R Tolentino, K Nguyen, L DAmico, E Barron, L Cheng, WR Freeman, and GA Silva (2009) Quantum dot labeling and imaging of GFAP intermediate filaments and gliosis in the rat neural retina and dissociated astrocytes. Journal of Nanoscience and Nanotechnology 9:5047-5054. PDF

F Mojana, L Cheng, D-WG Bartsch, GA Silva, I Kozak, N Nigam, and WR Freeman (2008) The role of abnormal vitreomacular adhesion in age-related macular degeneration: Spectral OCT and surgical results. American Journal of Ophthalmology 146:218-227. PDF

C MacDonald, D Yu, M Buibas, and GA Silva (2008) Diffusion modeling of ATP signaling suggests a partially regenerative mechanism underlies astrocyte intercellular calcium waves. Frontiers in Neuroengineering 1:1-13.

I Falkenstein, L Cheng, F Wong-Staal, A Tammewar, E Barron, GA Silva, Q-X Li, D Yu, G Liu, N Ke, J MacDonald, and WR Freeman (2008) Toxicity and intraocular properties of a novel long acting anti-proliferative and anti-angiogenic compound IMS2186. Current Eye Research 33:599-609.

M Hashemi, M Buibas, and GA Silva (2008) Automated detection of intercellular signaling in astrocyte networks using the converging squares algorithm. Journal of Neuroscience Methods 170:294-299. PDF

S Pathak, MC Davidson, and GA Silva (2007) Characterization of the functional binding properties of antibody conjugated quantum dots. NanoLetters 7:1839-1845. PDF

I Kozak, OR Kayikcioglul, Cheng, I Falkenstein, GA Silva, D Yu, and WR Freeman (2006) The effect of recombinant human hyaluronidase on dexamethasone penetration into the posterior segment of the eye after sub-Tenon’s injection. Journal of Ocular Pharmacology and Therapeutics 22:362-369.

M Ho, D Yu, MC Davidson, and GA Silva (2006) Comparison of standard surface chemistries for culturing mesenchymal stem cells prior to neural differentiation. Biomaterials 27:4333-4339. PDF

S Pathak, E Cao, MC Davidson, S Jin, and GA Silva (2006) Quantum dot applications in neuroscience: New tools for probing neurons and glia. Journal of Neuroscience 26:1893-1895. PDF

GA Silva, C Czeisler, KL Niece, E Beniash, D Harrington, JA Kessler, and SI Stupp (2004) Selective differentiation of neural progenitor cells by high-density epitope nanofibers. Science 303:1352-1355. PDF

GA Silva and DR Pepperberg (2004) Step response of mouse rod photoreceptors modeled in terms of elemental photic signals. IEEE Transactions on Biomedical Engineering 51:3-12. PDF

GA Silva, JR Hetling, and DR Pepperberg (2001) Dynamic and steady-state light adaptation of mouse rod photoreceptors in vivo. Journal of Physiology 534:203-216. PDF

GA Silva, E Theriault, LR Mills, PS Pennefather, and CJ Feeney (1999) Group I and II metabotropic glutamate receptor expression in cultured rat spinal cord astrocytes. Neuroscience Letters 263:117- 120. PDF

GA Silva, CJ Feeney, LR Mills, and E Theriault (1998) A novel and rapid method for culturing pure rat spinal cord astrocytes on untreated glass. Journal of Neuroscience Methods 80: 75-79. PDF

Invited Reviews and Commentaries

GA Silva and ML Khraiche (2013) Nanotechnologies for recording and stimulating from excitable cells. Discovery Medicine 15:357-365.

A Devor, PA Bandettini, DA Boas, JM. Bower, RB. Buxton, M Carandini, LB. Cohen, AM. Dale, GT Einevoll, P Fox, MA Franchescini, K Friston, JG Fujimoto, MA Geyer, JH Greenberg, E Halgren, MS. Hämäläinen, KD Harris, M Häusser, F Helmchen, BT Hyman, A Jasanoff, TL Jernigan, LL Judd, S-G Kim, D Kleinfeld, NJ Kopell, M Kutas, KK Kwong, ME Larkum, EH. Lo, PJ Magistretti, JB Mandeville, E Masliah, PP Mitra, WC Mobley, CI Moore, MA Moskowitz, A Nimmerjahn, JH Reynolds, BR Rosen, BM Salzberg, CB Schaffer, GA Silva, PTC. So, NC Spitzer, RB Tootell, DC Van Essen, W Vanduffel, SA Vinogradov, LL Wald, LV Wang, B Weber, AG. Yodh (2013) The challenge of connecting the dots in B.R.A.I.N. Neuron 80:270-274.

V Parpura GA Silva, PA Tass, KE Bennet, M Meyyappan, J Koehne, KH Lee, and RJ Andrews (2012) Neuromodulation: selected approaches and challenges. Journal of Neurochemistry 10.1111/jnc.12105

J Blumling and GA Silva (2012) Targeting the brain: Advances in drug delivery. Journal of Current Pharmaceutical Biotechnology 13:2417-2426

GA Silva (2011) The need for the emergence of mathematical neuroscience: Beyond computation and simulation. Frontiers in Computational Neuroscience 5:51. doi: 10.3389/fncom.2011.0005.

GA Silva (2010). Nanotechnology applications and approaches for neuroregneration and drug delivery to the CNS. Annals of the New York Academy of Sciences 1199:221-230.

GA Silva (2009) Shorting neurons with carbon nanotubes. Nature Nanotechnology. 4:82-83.

GA Silva (2009). Quantum dot nanotechnologies for neuroimaging. Progress in Brain Research 180:17-32.

JM Provenzale and GA Silva (2009) Use of nanoparticles to central nervous system imaging and therapy. American Journal of Neuroradiology 10.3174/ajnr.A1590:1-9.

NA Kotov*, JO Winter*, I Clements, E Jan, BP Timko, S Campiedelli, S Pathak, A Mazzatenta, CM Lieber*, M Prato*, RV Bellamkonda*, GA Silva*, NWS Kam, F Patolsky, and L Ballerini (2009) Nanomaterials for neural interfaces. Advanced Materials 21:1-35. (*corresponding authors)

GA Silva (2008) The central nervous system. Drug Discovery Today: Disease Models 5:1-3.

GA Silva (2008) Nanotechnology approaches for crossing the blood brain barrier and drug delivery to the CNS. BMC Neuroscience 9(Suppl 3):S4, 1-4.

D Yu and GA Silva (2008) Stem cell sources and therapeutic approaches for central nervous system and neural retinal disorders. Neurosurgical Focus 24:E10, 1-14.

GA Silva (2007) Nanotechnology approaches for drug and small molecule delivery across the blood brain barrier. Surgical Neurology 67:113-116.

GA Silva (2007) What impact will nanotechnology have on neurology? Nature Clinical Practice Neurology. 1:92-94.

I Kozak, L Cheng, GA Silva, and RF Freeman (2007) Testing of intraocular drugs for clinical use. Investigative Ophthalmology and Visual Sciences 48:4861-4863. PDF

GA Silva (2007) Nanotechnology approaches for drug and small molecule deliver across the blood brain barrier.  Surgical Neurology 67:113-116

GA Silva (2006) Neuroscience nanotechnology: Progress, challenges, and opportunities. Nature Reviews Neuroscience 7:65-74.

GA Silva (2006) Nanomedicine: Seeing the benefits of ceria. Nature Nanotechnology 1:92-94.

GA Silva (2005) Small Neuroscience: The nanostructure of the central nervous system and emerging nanotechnology applications. Current Nanoscience 1:225-236.

GA Silva (2005) Nanotechnology approaches for the regeneration and neuroprotection of the central nervous system. Surgical Neurology 63:301-306

Books and Book Chapters

GA Silva and V Parpura. Editors. (2011) Nanotechnology for Biology and Medicine: At the Building Block Level. Springer Life Sciences, New York, New York. ISBN 978-0-387-31282-8.

GA Silva (2011) Quantum dots for cellular neural imaging. In: Nanotechnology for Biology and Medicine: At the Building Block Level. Springer Life Sciences, New York, New York. ISBN 978-0-387-31282-8.

GA Silva (2008) The structure of the nervous system and nanoengineering approaches to studying it and repairing it. In: Introduction to Bioengineering pp. 327-351. S Chien and P Chang, Editors. World Scientific Press, Hackensack, New Jersey. ISBN 978-981-270-793-2.

GA Silva (2007) The nanostrcutrue of the nervous system and the impact of nanotechnology on neuro- science. In: United Nations Educational, Scientific, and Cultural Organization (UNESCO) Encyclopedia of Life Support Systems (EOLSS). H Doelle, Editor, Biotechnology Theme. UNESCO Publishing-EOLSS Publishers, Oxford, UK.

GA Silva (2005) Bionanotechnology applications to the central nervous system. In: Exploring Nanotechnology multimedia CD ROM. Nanopolis Distributed Knowledge Network in Science and Engineering.